Organic Chemistry II

This course deepens your understanding of the complex reactions and properties of organic molecules. Learn about a range of topics, including alcohols, ethers, and related compounds; oxidation and reduction reactions; among others.

What you’ll learn

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Organic Chemistry II

$79

Plus membership

3 Credits

All courses include:

eTextbooks

2 to 3-day turnaround for grading

Multiple chances to improve your grade

On-demand tutoring & writing center

Student support 7 days a week

$79

Plus membership

3 Credits

All courses include:

eTextbooks

2 to 3-day turnaround for grading

Multiple chances to improve your grade

On-demand tutoring & writing center

Student support 7 days a week

Organic Chemistry II

$79

Plus membership

3 Credits

About This Course

|
ACE Approved 2023

Taking Organic Chemistry II online will build on your foundational knowledge of organic chemistry to deepen your understanding of the complex reactions and properties of organic molecules.

download syllabus

What You'll Learn

Predict the appearance of product(s) of a dehydration reaction, Sn1 reaction, or epoxide ring opening.

Predict the appearance of product(s) of a alkene dihydroxylation or ozonolysis reaction.

Using the inscribed polygon method to determine if a compound is aromatic.

Predict the appearance of product(s) from a monosubstituted, disubstituted, or trisubstituted benzene with an electrophile.

Predict the appearance of all stereoisomers that form in a Grignard reaction.

Predict the appearance of stereoisomers that form in the intramolecular cyclization of a hydroxy aldehyde.

Rank benzoic acids in order of increasing acidity.

Determine the carboxylic acid and alcohol needed for a Fischer esterification.

Use retrosynthetic analysis in a reductive amination.

Use spectroscopy to identify compounds.

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Course Details

CHEM251

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Organic Chemistry II

Organic Chemistry II covers a wide range of topics, including alcohols, ethers, and related compounds, oxidation and reduction reactions, benzene and aromatic compounds, reactions of aromatic compounds, introduction to carbonyl chemistry, aldehydes and ketones, carboxylic acids and nitriles, and amines.

Prerequisites

There are no prerequisites to take Organic Chemistry II though we highly recommend concurrent enrollment in Organic Chemistry I (CHEM250).

Topic Subtopics
Alcohols, Ethers, and Related Compounds
  • Structure and Bonding
  • Nomenclature
  • Properties of Alcohols, Ethers, and Epoxides
  • Interesting Alcohols, Ethers, and Epoxides
  • Preparation of Alcohols, Ethers, and Epoxides
  • General Features— Reactions of Alcohols, Ethers, and Epoxides Dehydration of Alcohols to Alkenes
  • Carbocation Rearrangements
  • Dehydration Using POCl3 and Pyridine
  • Conversion of Alcohols to Alkyl Halides with HX
  • Conversion of Alcohols to Alkyl Halides with SOCl2 and PBr3
  • Tosylate—Another Good Leaving Group
  • Reaction of Ethers with Strong Acid
  • Thiols and Sulfides
  • Reactions of Epoxides
  • Application: Epoxides, Leukotrienes, and Asthma
  • Application: Benzo[α]pyrene, Epoxides, and Cancer
Oxidation and Reduction
  • Reducing Agents
  • Reduction of Alkenes
  • Application: Hydrogenation of Oils
  • Reduction of Alkynes
  • The Reduction of Polar C─X σ Bonds
  • Oxidizing Agents
  • Epoxidation
  • Dihydroxylation
  • Oxidative Cleavage of Alkenes
  • Oxidative Cleavage of Alkynes
  • Oxidation of Alcohols
  • Green Chemistry
  • Biological Oxidation
    • Sharpless
  • Epoxidation
Benzene and Aromatic Compounds
  • The Structure of Benzene
  • Nomenclature of Benzene Derivatives
  • Spectroscopic Properties
  • Interesting Aromatic Compounds
  • Benzene’s Unusual Stability
  • The Criteria for Aromaticity— Hückel’s Rule
  • Examples of Aromatic Compounds Aromatic
  • Heterocycles
  • What Is the Basis of Hückel’s Rule?
  • The Inscribed Polygon Method for Predicting Aromaticity
Reactions of Aromatic Compounds
  • Electrophilic Aromatic Substitution
  • The General Mechanism
  • Halogenation
  • Nitration and Sulfonation
  • Friedel–Crafts Alkylation and Friedel–Crafts Acylation
  • Substituted Benzenes
  • Electrophilic Aromatic Substitution of Substituted Benzenes
  • Why Substituents Activate or Deactivate a Benzene Ring
  • Orientation Effects in Substituted Benzenes
  • Limitations on Electrophilic Substitution Reactions with Substituted Benzenes
  • Disubstituted Benzenes
  • Synthesis of Benzene Derivatives
  • Nucleophilic Aromatic Substitution
  • Reactions of Substituted Benzenes
  • Multistep Synthesis
Introduction to Carbonyl Chemistry: Organometallic Reagents; Oxidation and Reduction
  • General Reactions of Carbonyl Compounds
  • A Preview of Oxidation and Reduction
  • Reduction of Aldehydes and Ketones
  • The Stereochemistry of Carbonyl Reduction
  • Enantioselective Carbonyl Reductions
  • Reduction of Carboxylic Acids and Their Derivatives
  • Oxidation of Aldehydes
  • Organometallic Reagents
  • Reaction of Organometallic Reagents with Aldehydes and Ketones
  • Retrosynthetic Analysis of Grignard Products
  • Protecting Groups
  • Reaction of Organometallic Reagents with Carboxylic Acid Derivatives
  • Reaction of Organometallic Reagents with Other Compounds
  • α,β-Unsaturated Carbonyl Compounds
  • Summary—The Reactions of Organometallic Reagents
  • Synthesis
Aldehydes and Ketones— Nucleophilic Addition
  • Nomenclature Properties of
  • Aldehydes and Ketones
  • Interesting Aldehydes and Ketones
  • Preparation of Aldehydes and Ketones
  • Reactions of Aldehydes and Ketones—General Considerations
  • Nucleophilic Addition of H– and R–—A Review
  • Nucleophilic Addition of –CN
  • The Wittig Reaction
  • Addition of 1° Amines
  • Addition of 2° Amines
  • Addition of H2O— Hydration
  • Addition of Alcohols —Acetal Formation
  • Acetals as Protecting Groups
  • Cyclic Hemiacetals
  • An Introduction to Carbohydrates
Carboxylic Acids and Nitriles
  • Structure and Bonding
  • Nomenclature
  • Physical and Spectroscopic Properties
  • Interesting Carboxylic Acids and Nitriles
  • Aspirin, Arachidonic Acid, and Prostaglandins
  • Preparation of Carboxylic Acids
  • Carboxylic Acids— Strong Organic Brønsted–Lowry Acids
  • Inductive Effects in Aliphatic Carboxylic Acids
  • Substituted Benzoic Acids
  • Extraction
  • Amino Acids
  • Nitriles
Carboxylic Acids and Their Derivatives-Nucleophilic Acyl Substitution
  • Structure and Bonding
  • Nomenclature
  • Physical and Spectroscopic Properties
  • Interesting Esters and Amides
  • Introduction to Nucleophilic Acyl Substitution
  • Reactions of Acid Chlorides
  • Reactions of Anhydrides
  • Reactions of Carboxylic Acids
  • Reactions of Esters
  • Application: Lipid Hydrolysis Reactions of Amides
  • Application: The Mechanism of Action of β-Lactam Antibiotics
  • Summary of Nucleophilic Acyl Substitution Reactions
  • Natural and Synthetic Fibers
  • Biological Acylation Reactions
Amines
  • Introduction
  • Structure and Bonding
  • Nomenclature
  • Physical and Spectroscopic Properties
  • Interesting and Useful Amines
  • Preparation of Amines
  • Reactions of Amines —General Features
  • Amines as Bases
  • Relative Basicity of Amines and Other Compounds
  • Amines as Nucleophiles
  • Hofmann Elimination
  • Reactions of Amines with Nitrous Acid
  • Substitution Reactions of Aryl Diazonium Salts
  • Coupling Reactions of Aryl Diazonium Salts
  • Application: Synthetic Dyes and Sulfa Drugs

Your score provides a percentage score and letter grade for each course. A passing percentage is 70% or higher.

Assignments for this course include:

  • Graded Exam 1
  • Graded Exam 2
  • Graded Exam 3
  • Graded Exam 4


The required eTextbook for this course is included with your course purchase at no additional cost.


Smith, Janice. Organic Chemistry. 7th ed., McGraw Hill, 2024. ISBN:9781264141531


Organic Chemistry students also take:

Organic Chemistry II Lab

Biochemistry

Biochemistry Lab

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